After the first-leg results, the odds were stacked against the National Teamers Abroad clubs looking to advance in the Europa League quarterfinals. Jermaine Jones's Schalke 04 drew Bilbao 2-2 on the night, exiting the tournament 6-4 on aggregate. Jones got the start with Klaas-Jan Huntelaar (28th) and Raul (52nd) scoring. Steve Cherundolo started for Hannover 96, exiting to Atletico Madrid after losing 2-1 on the night and 4-2 on aggregate. Mame Biram Diouf equalized for Hannover in the 81st minute, but Atletico would score in the 87th for the win. Atletico picked up five yellow cards in the game. Jozy Altidore started and played 68 minutes for AZ, losing 4-0 on the night to Valencia and 5-2 on aggregate.
With Oguchi Onyewu recovering from an injury, Sporting advanced 3-2 on aggregate after drawing Metalist 1-1. Sporting advance to play Bilbao in a semifinal stage dominated by La Liga clubs.